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Regulating Leptin May Be The Key to Fat Loss
Leptin from the Greek “leptos” which means slim or refined is a 16 kDa protein hormone consisting of 167 amino acids which is in part in charge forgoverning appetite and metabolism. It isissued from fat cells and relays the status of fat stores to the hypothalamus.
This hormone had it’s beginnings in 1950 Cheap Mika Zibanejad Jersey , when researchers at The Jackson Laboratory in Bar Harbor, Maine, noticed that they had a strain of mutant mice that were obese, lethargic, insulin-resistant and constantly hungry. When they gave the obese mice leptin supplements Cheap Pavel Buchnevich Jersey , the animals lost weight which was predominantly fat loss, became more active and began responding to insulin.
The amount of leptin working its way through the body is directly related to the total amount of fat in the body. Human and animal research indicates that it may play aninfluential role in fat loss and obesity-related cardiovascular disease. Recent examinations suggest that the cardiovascular actions of leptin may help explain the link between excess fat mass and cardiovascular diseases. It is produced by a specific gene found in fat cells called the obese or (ob) gene. Small amounts of leptin are also secreted by cells in the epithelium, stomach and placenta. The amount of leptin found in people increases as their body fat increases. One theory is that as you get fatter you also get less attuned to the affects of leptin. This is why fat loss may be more than just cutting calories.
Let’s see how it acts on the body to promote fat loss in the following ways;
? counteracts the effects of neuropeptide Y which is a feeding stimulant secreted by cells in the gut wall and in the hypothalmus
? counteracts the affects of anandamid which is another feeding stimulant that binds to the same receptors as THC
? promotes the effects of alpha-MSH which is an anti-inflammatory agent and another appetite-suppressing hormone which results in you eating less and greater fat loss
? it also stimulates secretion of reproductive hormones such as gonadotrophin-releasing hormone and thus leutenizing and follicle stimulating hormone from the anterior pituitary.
? it raises t